It is widely believed by philosophers that we human beings are capable of stepping back from inclinations to act in a certain way and consider whether we should do so. If we judge that there are enough reasons in favour of following our initial inclination, we are definitely motivated, and, if all goes well, we act. This view of human agency naturally leads to the idea that our actions are self-determined, or controlled by ourselves. Some go one step further to (...) the point of saying that we should extend the fundamental aspects of this view of human agency to the epistemic realm. This we call ‘the control-view”. Here we will make a strong case against the control-view. While we have a substantial control over our practical lives, it is very unlikely that this extends to our epistemic lives. Our discussion will proceed in three stages. We will present two asymmetries between our practical and epistemic lives which are followed by a general argument against the control-view. (shrink)

This paper makes a plea for more reflexive attempts to develop and anchor the emerging concept of responsible research and innovation. RRI has recently emerged as a buzzword in science policy, becoming a focus of concerted experimentation in many academic circles. Its performative capacity means that it is able to mobilise resources and spaces despite no common understanding of what it is or should be ‘made of’. In order to support reflection and practice amongst those who are interested in and (...) using the concept, this paper unpacks understandings of RRI across a multi-disciplinary body of peer-reviewed literature. Our analysis focuses on three key dimensions of RRI that remain particularly opaque. A total of 48 publications were selected through a systematic literature search and their content was qualitatively analysed. Across the literature, RRI is portrayed as a concept that embeds numerous features of existing approaches to govern and assess emerging technologies. Our analysis suggests that its greatest potential may be in its ability to unify and provide political momentum to a wide range of long-articulated ethical and policy issues. At the same time, RRI’s dynamism and resulting complexity may represent its greatest challenge. Further clarification on what RRI has to offer in practice—beyond what has been offered to date—is still needed, as well as more explicit engagement with research and institutional cultures of responsibility. Such work may help to realise the high political expectations that are attached to nascent RRI. (shrink)

The distribution pattern of the meiotic machinery in known eukaryotes is most parsimoniously explained by the hypothesis that all eukaryotes are ancestrally sexual. However, this assumption is questioned by preliminary results, in culture conditions. These suggested that Acanthamoeba, an organism considered to be largely asexual, constitutively expresses meiosis genes nevertheless—at least in the lab. This apparent disconnect between the “meiosis toolkit” and sexual processes in Acanthamoeba led to the conclusion that the eukaryotic ancestor is asexual. In this review, the “meiosis (...) toolkit” is rigorously defended, drawing on numerous research articles. Additionally, the claim of constitutive meiotic gene expression is probed in Acanthamoeba via the same transcriptomics data. The results show that the expression of the meiotic machinery is not constitutive in Acanthamoeba as claimed before. Furthermore, it is argued that this would have no implications for understanding the nature of the eukaryotic ancestor, regardless of the result. (shrink)

Cartesian representationalism and the Enlightenment heritage more broadly continue to play a pivotal role in shaping the 21st-century human scientific theory and practice. This introduction to a special section on the topic surveys some aspects of that heritage.

This study examined individual, task, and environmental constraints that influence the career progression of youth Brazilian elite basketball players and the probability of reaching Novo Basquete Brasil and to determine if the association of the relative age effect is a key factor in the career progression. The sample consisted of 4,692 male players who were registered to participate in at least one U15, U17, or U22 youth Brazilian basketball championship between 2004 and 2018. Athletes who reached a high-performance level were (...) coded like NBB players. The birthdates, height, body mass, playing position, geographic region, club, competition category, and team performance were retrieved from the official data archive of the Brazilian Basketball Confederation and the National Basketball League. The maturity status was estimated using the predicted age at peak height velocity. A binary logistic regression examined the influence of each characteristic on the probability of a youth Brazilian basketball player to reach the NBB. The receiver operating characteristic curves and the associated area under the curve were used to assess the discriminant ability of the model. The taller and younger players not selected early into national teams, without specialization by playing position, who participated in U22 national championship, migrated to the southeast region, and remained in the formation process over time have a greater chance to reach the NBB. The ROC curve demonstrated an AUC of 93%. A combination of individual, task, and environmental characteristics influences the sport career of a young Brazilian basketball player in reaching the NBB. Further, early-maturing athletes have a greater chance to reach higher performances. RAE influences lower-level categories, but not a “NBB player's” career progression. The coaches, stakeholders, and practitioners should perform a holistic evaluation of sport talent in terms of a constraint-based theoretical model with the aim of avoiding bias produced by the maturational status and RAE in the youth Brazilian elite basketball. (shrink)

Our goal was to explore self‐care practices among men who have sex with men in the context of Mpox in Brazil. This study used qualitative research methods, including interviews and thematic analysis, to collect and analyze data from male participants across the Brazilian territory. The narratives unveil men's perspectives on self‐care, risk reduction, and health beliefs during the Mpox pandemic. Our findings highlight a multifaceted approach to self‐care among men, encompassing hygiene, physical contact management, mask usage, skin lesion vigilance, and (...) adherence to official guidelines. Men's attitudes toward sexual behaviors emphasize the importance of reducing sexual partners, practicing safe sex, and combating misinformation through accurate information dissemination. The development of these behaviors and self‐care practices can be facilitated by nurses guided by Dorothea Orem's Self‐Care Theory, supported by patient‐centered care, with strategies to address and confront the stigma associated with the disease and provide emotional support. Thus, the study underscores the pivotal role of self‐care in mitigating infection risks, especially in the context of emerging infectious diseases. It acknowledges the impact of socio‐cultural factors and healthcare policies on men's preventive measures. However, it also recognizes limitations, such as potential bias due to stigma concerns and a nonrepresentative sample. Ultimately, the research advocates for tailored education, promotion of gender equity, and healthcare empowerment to effectively manage health risks in such contexts. (shrink)

Neurosurgery for psychiatric disorders, also sometimes referred to as psychosurgery, is rapidly evolving, with new techniques and indications being investigated actively. Many within the field have suggested that some form of guidelines or regulations are needed to help ensure that a promising field develops safely. Multiple countries have enacted specific laws regulating NPD. This article reviews NPD-specific laws drawn from North and South America, Asia and Europe, in order to identify the typical form and contents of these laws and to (...) set the groundwork for the design of an optimal regulation for the field. Key challenges for this design that are revealed by the review are how to define the scope of the law, what types of regulations are required, and how to approach international harmonization given the potential migration of researchers and patients. (shrink)

Placebo-controlled trials are controversial when individuals might be denied existing beneficial medical interventions. In the case of malaria, most patients die in rural villages without healthcare facilities. An artesunate suppository that can be given by minimally skilled persons might be of value when patients suddenly become too ill for oral treatment but are several hours from a facility that can give injectable treatment for severe disease. In such situations, by default, no treatment is (or can be) given until the patient (...) reaches a facility, making the placebo control design clinically relevant; alternative bioequivalence designs at the facility would misrepresent reality and risk incorrect conclusions. We describe the ethical issues underpinning a placebo-controlled trial in severe malaria. To protect patients and minimise risk, all patients were referred immediately to hospital so that each had a higher chance of prompt treatment through participation. There was no difference between artesunate and placebo in patients who reached clinic rapidly; among those who could not, a single artesunate suppository significantly reduced death or permanent disability, a finding of direct and indirect benefit to patients in participating villages and elsewhere. (shrink)

Heterogeneity within MDD has hampered identification of biological markers (e.g., intermediate phenotypes, IPs) that might increase risk for the disorder or reflect closer links to the genes underlying the disease process. The newer characterizations of dimensions of MDD within Research Domain Criteria (RDoC) domains may align well with the goal of defining IPs. We compare a sample of 25 individuals with MDD compared to 29 age and education matched controls in multimodal assessment. The multimodal RDoC assessment included the primary IP (...) biomarker, positron emission tomography (PET) with a selective radiotracer for 5-HT1A ([11C]WAY-100635), as well as event-related functional MRI with a Go/No-go task targeting the Cognitive Control network, neuropsychological assessment of affective perception, negative memory bias and Cognitive Control domains. There was also an exploratory genetic analysis with the serotonin transporter (5-HTTLPR) and monamine oxidase A (MAO-A) genes. In regression analyses, lower 5-HT1A binding potential (BP) in the MDD group was related to diminished engagement of the Cognitive Control network, slowed resolution of interfering cognitive stimuli, one element of Cognitive Control. In contrast, higher/normative levels of 5-HT1A BP in MDD (only) was related to a substantial memory bias toward negative information, but intact resolution of interfering cognitive stimuli and greater engagement of Cognitive Control circuitry. The serotonin transporter risk allele was associated with lower 1a BP and the corresponding imaging and cognitive IPs in MDD. Lowered 5HT 1a BP was present in half of the MDD group relative to the control group. Lowered 5HT 1a BP may represent a subtype including decreased engagement of Cognitive Control network and impaired resolution of interfering cognitive stimuli. Future investigations might link lowered 1a BP to neurobiological pathways and markers, as well as probing subtype-specific treatment targets. (shrink)

O propósito geral deste artigo consiste em mostrar, a partir de hipóteses globais de interpretação da natureza e da arte, o lugar da pintura na filosofia de F. W. J. v. Schelling. Submetendo a obra pictórica a condições teórico-especulativas inovadoras, a ponderação schellinguiana impele-nos, não raro, a um tratamento diferenciado do visível. Por isso, a título de exercício de reflexão, espera-se igualmente indicar que tal caracterização da pintura ecoa e antecipa, ao longe, questões levantadas pela filosofia contemporânea – em especial, (...) pela fenomenologia – a respeito da imagem. (shrink)

A cooperação equitativa é um conceito central da filosofia de John Rawls e possui uma estreita relação com as noções de racionalidade, razoabilidade e tolerância. Portanto, faz-se necessário ressaltar que tais temas são fundamentais para uma adequada compreensão da teoria rawlsiana de justiça. Rawls elege a justiça como virtude primária e princípio norteador na construção da sua teoria. Em virtude disso, a preocupação de Rawls é a resolução das desigualdades sociais que ocorrem nos sistemas políticos democráticos. A noção de justiça (...) como equidade faz-se indispensável frente à necessidade de eleger a liberdade enquanto preocupação com o justo equilíbrio e ao “consenso nas sociedades plurais”. É a partir da concepção de cooperação equitativa que Rawls tenta resolver o impasse contemporâneo da convivência de diferentes doutrinas abrangentes razoáveis sejam elas, religiosas, filosóficas ou morais. Dessa forma, a teoria rawlsiana de justiça tem como proposta a “coexistência pacifica” ante essa pluralidade de doutrinas compreensivas. Assim posto, a justiça como equidade, pode plausivelmente, ser a forma mais viável de coexistência pacífica que agrupamentos sociais poderiam seguir ou se pautar. Sob essa ótica, acredita-se que a noção de cooperação equitativa rawlsiana será uma via de justiça que enfatiza os direitos individuais sem desmerecer aquilo que é próprio do coletivo. Abstrac t: Fair cooperation is a central concept of J. Rawls´s philosophy and keeps a close relationship with the the notions of rationality, reasonability, and tolerance. Thus it is important to claim that these notions are necessary for a correct comprehension of rawlsian theory of justice. Rawls claims justice as the primary virtue and main principle of his theory. The aim of Rawls is to solve the social inequalities that occur in democratic political systems. The concept of justice as fairness is essential before the need of electing the liberty as concerning to the just balance and to the “consensus in the plural societies”. By starting from the conception of fair cooperation Rawls tries to solve the contemporary problem of different comprehensive doctrines sharing the same political and social space, no matter they are religious, philosophical or moral ones. The rawlsian theory of justice claims to propose as “pacific cohabitation” among that plurality of comprehensive doctrines. In this way, justice as fairness may plausibility be the most viable form of pacific cohabitation that social groups can follow or be ruled. Under this perspective, we believe that the rawlsian concept of fair cooperation will be a way of justice that focus on individual rights without deprive the significance of collective. Keywords : Rawls, fair cooperation, original position, rationality, reasonability. (shrink)

Nosso artigo irá avaliar a contribuição de uma teoria intensional para projetos de filosofia da ciência. Esperamos explorar o conceito de intensão, que fez parte da polêmica semântica do século XX, para discutir a natureza dos enunciados da ciência e suas diferenças de profundidade. Optamos por dar a seguinte forma à argumentação: almejamos apresentar indícios para a plausibilidade da tese de que as intensões contribuem para marcar diferenças de conteúdo preditivo das proposições. Argumentaremos que essas diferenças falham em ser avaliadas (...) extensionalmente. Sugerimos explorar a diferença entre intensões carnapianas (Carnap 1891-1970) e millianas (Stuart Mill 1806-1873). A linha de contraste será traçada a partir dos problemas para os quais os autores elaboraram seu conceito: as primeiras para ampliar o universo extensional da interpretação com casos possíveis mapeados por um modelo (as quais chamaremos de extensionalidade estendida), e as segundas para resolver problemas de profundidade teórica, entendidos como questões de projeção e predição. A sequência do artigo avalia o desafio de Quine à concepção carnapiana de intensão, e explora a seguinte opção: a de que uma versão profunda (milliana) do conceito de intensão e analiticidade não seria alvo da crítica de Quine. Passamos, por fim, por um exame de possíveis alinhamentos e alianças com o racionalismo crítico recente (David Miller, J. Watkins), para concluir que o universo da filosofia da ciência está aberto a discutir a contribuição de uma noção não-extensional de significação. (shrink)

O texto a seguir, intitulado “Ensaio Histórico sobre a Cavalaria e a Honra dos Modernos”, foi escrito durante a juventude de David Hume, certamente antes da publicação do Tratado da Natureza Humana. Ainda não há consenso inabalável sobre o ano em que esse ensaio foi produzido. John Hill Burton, que o publicou pela primeira vez, em 1846, considera que Hume o teria escrito em 1727, logo após deixar o Edimburgh College. J. Y. T. Greig propõe uma conjectura um pouco mais, (...) por assim dizer, elástica, considerando que o texto deve ter sido escrito no período de 1729 a 1734. (shrink)

I argue that Before Sunrise, Before Sunset, and Before Midnight are best seen as an example of memento mori art. Memento mori, the admonition to remember death, can take many forms, but the idea remains the same, namely that an awareness of our inevitable end should bear on how we live. I show how Richard Linklater’s warning works in each of the movies and argue that with the Before trilogy he makes a Frankfurt-style case that romantic love is life’s summum (...) bonum--i.e. "the ultimate ground of practical rationality.". (shrink)

Contracts play an important role in business management where relationships among different parties are dictated by legal rules. Electronic contracts have emerged mostly due to technological advances and electronic trading between companies and customers. New challenges have then arisen to guarantee reliability among the stakeholders in electronic negotiations. In this scenario, automatic verification of electronic contracts appeared as an imperative support, specially the conflict detection task of multi-party contracts. The problem of checking contracts has been largely addressed in the literature, (...) but there are few, if any, methods and practical tools that can deal with multi-party contracts using a contract language with deontic and dynamic aspects as well as relativizations, over the same formalism. In this work we present an automatic checker for finding conflicts on multi-party contracts modeled by an extended contract language with deontic operators and relativizations. Moreover a well-known case study of sales contract is modeled and automatically verified by our tool. Further, we performed practical experiments in order to evaluate the efficiency of our method and the practical tool. (shrink)